- Original Article
- Effect of GnRH analogue on the bone mineral density of precocious or early pubertal girls
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Jeong Sook Lim, Heon-Seok Han
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Clin Exp Pediatr. 2009;52(12):1370-1376. Published online December 15, 2009
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Purpose : Treatment of precocity with gonadotropin releasing hormone analogue (GnRHa) might theoretically exert a detrimental effect on the bone mass during pubertal development. We investigated the short-term changes in bone mineral density (BMD) during GnRHa treatment and the enhancement in the changes with the co-administration of GnRHa and human growth hormone (hGH).
Methods : Forty girls with precocious or... |
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